Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedlclne

Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe3O4 nanoparticles with diblock copolymer folate-poly（ethylene glycol）-b-poly（glycerol monomethacrylate） （FA-PEG-b- PGMA）, and triblock copolymer methoxy poly（ethylene glycol）-b-poly（2-（d...

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Bibliographic Details
Published in:高分子科学：英文版 2014 (10), p.1329-1337
Main Author: Yan Zhang Xiao-ju Wang Miao Guo Hu-sheng Yan Chen-hong Wang Ke-liang Liul
Format: Article
Language:English
Subjects:
二嵌段共聚物
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复合纳米粒子
多功能
甲基丙烯酸酯
磁铁矿
聚合物
顺铂
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Summary:Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe3O4 nanoparticles with diblock copolymer folate-poly（ethylene glycol）-b-poly（glycerol monomethacrylate） （FA-PEG-b- PGMA）, and triblock copolymer methoxy poly（ethylene glycol）-b-poly（2-（dimethylamino） ethyl methacrylate）-b- poly（glycerol monomethacrylate） （MPEG-b-PDMA-b-PGMA）. The PGMA segment was attached to the surfaces of Fe304 nanoparticles, and the outer PEG shell imparted biocompatibility. In addition, folate was conjugated onto the surfaces of the nanocarriers. Cisplatin was then loaded into the nanocarrier by coordination between the Pt atom in cisplatin and the amine groups in the inner shell of the multilayer architecture. The loaded cisplatin showed pH-responsive release： slower release at pH 7.4 （i.e. mimicking the blood environment） and faster release at more acidic pH （i.e. mimicking endosome/lysosome conditions）. All of the cisplatin-loaded nanoparticles showed concentration-dependent cytotoxicity in HeLa cells. However, the folate-conjugated cisplatin-loaded carriers exhibited higher cytotoxicity in HeLa cells than non-folate conjugated cisplatin-loaded carriers.
ISSN:0256-7679
1439-6203