Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae （DncV） responsible for synthesizing a hybrid cyclic GMP-AMP

Dear Editor, Through production of cyclic di-nucleotides as second messengers, di-nucleotide cyclases in bacteria and more recently in mammalian cells have been found to play important roles in modulating a wide range of cellular processes [1]. During infection of Fibrio cholerae （V. cholerae）, di-n...

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Published in:细胞研究：英文版 2014 (10), p.1270-1273
Main Author: Zhenhua Ming Wei Wang Yuchen Xie Pengfei Ding Yuchao Chen Dazhi Jin Yuna Sun Bin Xia Liming Yan Zhiyong Lou
Format: Article
Language:English
Subjects:
二核苷酸
合成
哺乳动物细胞
小说
晶体结构
混合循环
环化酶
霍乱弧菌
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Summary:Dear Editor, Through production of cyclic di-nucleotides as second messengers, di-nucleotide cyclases in bacteria and more recently in mammalian cells have been found to play important roles in modulating a wide range of cellular processes [1]. During infection of Fibrio cholerae （V. cholerae）, di-nucleotide cyclase Vibrio （DncV） is required for efficient intestinal colonization by 7. cholerae and downregulates hyperinfectivity-associated V.
ISSN:1001-0602
1748-7838