SCF^SImb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila

Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that ar...

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Bibliographic Details
Published in:细胞研究：英文版 2015 (1), p.93-109
Main Author: Hongtao Zhang Changqing Li Hanqing Chen Chuanxian Wei Fei Dai Honggang Wu Wen Dui Wu-Min Deng Renjie Jiao
Format: Article
Language:English
Subjects:
SCF
介导
果蝇
河马
膨化
连接酶
通路
降解
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Summary:Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCF^SImb E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded （Ex）. Mechanistic study shows that SImb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development.
ISSN:1001-0602
1748-7838