Treatment of hepatocellular carcinoma： Steps forward butstill a long way to go

Hepatocellular carcinoma （HCC） is the fifth mostcommon malignancy and the third cause of tumorassociated deaths worldwide. HCC incidence ratesare increasing in many parts of the world includingdeveloping and developed countries. Potentiallycurative treatments for HCC are resection and livertransplan...

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Bibliographic Details
Published in:世界肝病学杂志：英文版（电子版） 2015 (3), p.566-574
Main Author: Liat Mlynarsky Yoram Menachem Oren Shibolet
Format: Article
Language:English
Subjects:
carcinoma
Hepatocellular
Liver
Loco-ablative
resection
Liver
Sorafenib
therapies
transplantation
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Summary:Hepatocellular carcinoma （HCC） is the fifth mostcommon malignancy and the third cause of tumorassociated deaths worldwide. HCC incidence ratesare increasing in many parts of the world includingdeveloping and developed countries. Potentiallycurative treatments for HCC are resection and livertransplantation, but these are only suitable for patientswith small tumors, meeting strict pre-defined criteria, orwell-compensated liver disease. Early diagnosis of HCCcan be achieved by surveillance of at-risk populations.For patients with non-resectable disease treatmentsmodalities include loco-ablative and systemic therapies.In this review we focus on treatment options in HCCand their allocation. Although significant research is inprogress, to this date, the results are unsatisfactorywith limited long-term survival. In the fight against thisdeadly disease, there is still a long way to go.
ISSN:1948-5182
1948-5182