Lactulose enhances neuroplasticity to improve ：ognitive function in early hepatic encephalopathy

Lactulose is known to improve cognitive function in patients with early hepatic encephalopa- thy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy in...

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Published in:中国神经再生研究：英文版 2015, Vol.10 (9), p.1457-1462
Main Author: Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo
Format: Article
Language:English
Subjects:
Morris水迷宫
乳果糖
大鼠模型
患者
早期
神经可塑性
肝性脑病
认知功能障碍
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Summary:Lactulose is known to improve cognitive function in patients with early hepatic encephalopa- thy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cog- nitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.
ISSN:1673-5374