A facile synthesis of cyano-chlorins related to chlorophyll from formyl （pyro）-pheophorbide-α by a tandem transformation of the aldehyde into a nitrile group

A facile synthesis for cyanochlorin related to chlorophyll from a formyl-substituted chlorin, by the oxidation of methyl （pyro）pheophorbide-a, was accomplished. These readily available chlorin aldehydes were assembled together with hydroxylamine hydrochloride in a tandem process to produce the corre...

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Bibliographic Details
Published in:中国化学快报：英文版 2016 (5), p.789-794
Main Author: Na Gao Jia-Zhu Li Yan-Long Li Zhen Wang Jin-Jun Wang
Format: Article
Language:English
Subjects:
串联
二氢
叶绿素
氰基
简便合成
脱镁叶绿酸
腈基
醛
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Summary:A facile synthesis for cyanochlorin related to chlorophyll from a formyl-substituted chlorin, by the oxidation of methyl （pyro）pheophorbide-a, was accomplished. These readily available chlorin aldehydes were assembled together with hydroxylamine hydrochloride in a tandem process to produce the corresponding chlorin nitriles in moderate to good yields. The formation of chlorin nitrile was discussed and a possible mechanism for the corresponding cyanation reaction was tentatively proposed.
ISSN:1001-8417
1878-5964