Bioinformatic exploration of MTAl-regulated gene networks in colon cancer

Metastasis-associated gene 1 （MTA1） controls a series of biological processes in tumor progression. Tumor progression is a complex process regulated by a gene network. The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecular network and its cooper...

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Bibliographic Details
Published in:医学前沿：英文版 2016 (2), p.178-182
Main Author: Chunxiao Li Haijuan Wang Feng Lin Hui Li Tao Wen Haili Qian Qimin Zhan
Format: Article
Language:English
Subjects:
Notch
基因网络
基因调控网络
核苷酸切除修复
生物信息学
结肠癌
肿瘤转移
金属
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Summary:Metastasis-associated gene 1 （MTA1） controls a series of biological processes in tumor progression. Tumor progression is a complex process regulated by a gene network. The global cancer gene regulatory network must be analyzed to determine the position of MTA1 in the molecular network and its cooperative genes by further exploring the biological functions of this gene. We used TCGA data sets and GeneCards database to screen MTA1- related genes. GO and KEGG pathway analyses were conducted with DAVID and gene network analysis via STRING and Cytoscape. Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such as Wnt/Notch/nucleotide excision repair pathways. The findings also suggested that MTA1 demonstrates the closest relationship in a coregulation process with the key molecules AKT1, EP300, CREBBP, SMARCA4, RHOA, and CAD. These results lead MTAI exploration to an in-depth investigation in different directions, such as Wnt, Notch, and DNA repair.
ISSN:2095-0217
2095-0225