Design, Synthesis, Inhibiting HDACs Ability and Antitumor Activity of Pyrimidin-4（3H）-one Hydroxamate Derivatives

A series of novel pyrimidin-4（3H）-one hydroxamate derivatives was designed, synthesized and studied for their activities against histone deacetylases（HDACs）. The results indicate that all the compounds show HDACs inhibitiory activity. The antiproliferative activities of the compounds against HeLa an...

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Bibliographic Details
Published in:高等学校化学研究：英文版 2016 (4), p.576-580
Main Author: LU Haibin JIN Xiangqun JIN Yang HUANG Bangrui WANG Cheng WANG Chunhe MA Fangyuan CHEN Yuting LI Jiarui CONG Yu WANG Wenlong SONG Yuming MU Xupeng
Format: Article
Language:English
Subjects:
A549细胞
合成
嘧啶
异羟肟酸
抗肿瘤活性
组蛋白去乙酰化酶
衍生物
设计
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Summary:A series of novel pyrimidin-4（3H）-one hydroxamate derivatives was designed, synthesized and studied for their activities against histone deacetylases（HDACs）. The results indicate that all the compounds show HDACs inhibitiory activity. The antiproliferative activities of the compounds against HeLa and A549 cells were also investigated. The pharmacological results show compound 9g has potent activity in the enzymatic inhibition assay and cell-based assay.
ISSN:1005-9040
2210-3171