Synthesis of Novel 3-Substituted PyridothienopyrimidineDerivatives with Biological Evaluation as Antimicrobial Agents

Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′：4,5]thieno[3,2-d]pyrimidin-3（4H）-yl}acetohydrazide（5） with a variety of activereagents and chemicals. Structures of the newly synthesized compounds were established base...

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Bibliographic Details
Published in:高等学校化学研究：英文版 2016, Vol.32 (6), p.967-972
Main Author: Farag A. E1-Essawy Nader M. Boshta Ayman K. EI-Sawaf Areal A. Nassar Mohamed S. Khalafalah
Format: Article
Language:English
Subjects:
Antimicrobial
heterocycle
Nitrogen-containing
Pyridothienopyrimidine
Thieno[2,3-b]pyridine
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Summary:Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′：4,5]thieno[3,2-d]pyrimidin-3（4H）-yl}acetohydrazide（5） with a variety of activereagents and chemicals. Structures of the newly synthesized compounds were established based on spectral data.The resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some ofthem represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayedthe highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in MIC range of 0.12--1.95 μg/mL.
ISSN:1005-9040
2210-3171