Incorporation of NLR into NIH stratificationsystem increases predictive accuracy for surgically resected gastrointestinal stromal tumors

• Published in: 生物化学与生物物理学报：英文版 2017, Vol.49 (2), p.179-185
• Main Author: Anwei Xue Xiaodong Gao Yong Fang Ping Shu Jiaqian Ling Kuntang Shen Yihong Sun Jing Qin Xinyu Qin Yingyong Hou
• Format: Article
• Language: English
• Subjects: 卫生院; 手术切除; 掺入; 淋巴细胞; 研究院; 胃肠道; 间质; 预测精度
• ISSN: 1672-9145; 1745-7270

Previous studies have reported that preoperative neutrophil-to-lymphocyte （NLR） and platelet-to- lymphocyte ratios were prognostic for various types of cancers. The aim of this study was to investi- gate the predictive utilities of preoperative peripheral blood counts in patients with gastrointestinal stromal tumors （GISTs）. We enrolled 510 consecutive, previously untreated patients who underwent surgery for primary, localized GISTs. The relationship between recurrence-free survival and out- come variables was assessed by univariate and multivariate analyses, while the clinicopathologic relevance of NLR was determined using the Chi-square test. A preoperative NLR ≥2 was associated with poor prognosis in patients undergoing surgeries for primary, localized GISTs. It was an inde- pendent predictor only in patients classified as National Institutes of Health high risk but not in the entire population. Preoperative NLR is a feasible and reproducible peripheral biomarker that helps identify patients for intensive adjuvant therapy and frequent surveillance.