Enhancement of endocytic uptake of H IV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1

We previously used recombinant soluble gp41 （rsgp41） as a targetto screen a ntnnan oone marrow cul,~n library by the yeast two-hybrid assay, and we identified an HW-1 gp41-binding protein, human POB1 （the partner of RalBP1）. We found that the gp41- binding site was located at the C-term- inal region...

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Bibliographic Details
Published in:中国免疫学杂志：英文版 2017, Vol.14 (6), p.568-571
Main Author: Yue Tan Junyi Wang Shan Su Qian Wang Shibo Jiang Lu Lu Ying-Hua Chen
Format: Article
Language:English
Subjects:
CD4
gp41
HIV-1
上皮细胞
内吞作用
摄取
病毒
阴性
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Summary:We previously used recombinant soluble gp41 （rsgp41） as a targetto screen a ntnnan oone marrow cul,~n library by the yeast two-hybrid assay, and we identified an HW-1 gp41-binding protein, human POB1 （the partner of RalBP1）. We found that the gp41- binding site was located at the C-term- inal region （aa462-521） of POB1 and the POBl-binding site was on the N-term- inal heptad repeat （NHR） region of HIV-1 gp41.
ISSN:1672-7681
2042-0226