Pd（0）-Catalyzed Tandem One-Pot Reaction of Biphenyl Ketones/Aldehydes to the Corresponding Di-substituted Aryl Olefins

Synthesis of di-substituted aryl olefins via a Pd（0）-catalyzed cross-coupling reaction of biphenyl ketones/alde- hydes, tosylhydrazide, and aryl bromides （or benzyl halides） was developed. This methodology was achieved by one-pot two-step reactions involving the preparation of N-tosylhydrazones by r...

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Bibliographic Details
Published in:中国化学：英文版 2017, Vol.35 (7), p.1141-1148
Main Author: Yang Liu Ping Liu Yan Liu Yu Wei
Format: Article
Language:English
Subjects:
串联
二取代
交叉偶联反应
催化
反应合成
联苯
醛
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Summary:Synthesis of di-substituted aryl olefins via a Pd（0）-catalyzed cross-coupling reaction of biphenyl ketones/alde- hydes, tosylhydrazide, and aryl bromides （or benzyl halides） was developed. This methodology was achieved by one-pot two-step reactions involving the preparation of N-tosylhydrazones by reacting tosylhydrazide with biphenyl ketones/aldehydes, followed by coupling with aryl bromides （or benzyl halides） in the presence of Pd（PPh3）4 and lithium t-butoxide to produce various di-substituted aryl olefins in moderate to good yields.
ISSN:1001-604X
1614-7065