Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson＇s Disease

• Published in: 神经科学通报：英文版 2017, Vol.33 (5), p.501-509
• Main Authors: Qiaoling Zeng, Xiaojun Guan, Jason C. F. Law Yan Lun, Zhujing Shen, Tao Guo, Min Xuan, Quanquan Gu, Xiaojun Xu, Min Chen, Minming Zhang
• Format: Article
• Language: English
• Subjects: fMRI; 大脑活动; 帕金森病; 患者; 正相关关系; 辅助运动区; 运动皮层; 静息态
• ISSN: 1673-7067; 1995-8218

We used resting-state fMRI to evaluate longitu- dinal alterations in local spontaneous brain activity in Parkinson＇s disease （PD） over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up, and 27 age- and sex-matched normal controls. Regional homogeneity （ReHo） and voxel-based-morphometry （VBM） were used to identify differences in local sponta- neous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus. Moreover, there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson＇s Disease Rating Scale-III scores. VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions. We conclude that ReHo may be a suitable non-invasive marker of progression in PD.