Cerebral Dopamine Neurotrophic Factor： A Potential Therapeutic Agent for Parkinson＇s Disease

The application of neurotrophic factors （NTFs） is a promising therapeutic strategy for neurodegenerative disorders such as Parkinson＇s disease （PD）. Many NTFs have been reported to enhance the survival, regeneration, and differentiation of neurons and to induce synaptic plasticity. However, because...

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Bibliographic Details
Published in:神经科学通报：英文版 2017, Vol.33 (5), p.568-575
Main Authors: Tingting Tang, Yong Li, Qian Jiao, Xixun Du, Hong Jiang
Format: Article
Language:English
Subjects:
NTFS
中脑
临床治疗
多巴胺神经元
帕金森病
神经退行性疾病
胶质细胞源性神经营养因子
药物
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Summary:The application of neurotrophic factors （NTFs） is a promising therapeutic strategy for neurodegenerative disorders such as Parkinson＇s disease （PD）. Many NTFs have been reported to enhance the survival, regeneration, and differentiation of neurons and to induce synaptic plasticity. However, because of their potential side-effects and low efficacy after clinical administration, more potent treatments for neurodegenerative disorders are being sought. Cerebral dopamine neurotrophic factor （CDNF）, a newly-identified NTF homologous to mesencephalic astrocyte-derived NTF, is structurally and functionally different from other NTFs, providing new hope especially for PD patients. In various animal models of PD, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, neuroinflam- mation, and apoptosis. Recent progress in all facets of CDNF research has enabled researchers to better under- stand its beneficial effects in the treatment of PD.
ISSN:1673-7067
1995-8218