Cell cycle.independent roles of p19INK4d in human terminal erythropoiesis

Normally, cyclin interacts with cyclin-dependent kinase (CDK) to form a cyclin-CDK complex, which promotes cell cycle progression, whereas cyclin-dependent kinase inhibitor (CDKI) molecules inhibit the formation of cyclin- CDK complex, arresting cell cycle. Terminal erythropoiesis is closely coordin...

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Bibliographic Details
Published in:癌症：英文版 2017, Vol.36 (4), p.163-164
Main Authors: Xu Han, Jing Liu
Format: Article
Language:English
Subjects:
roles
erythropoiesis
CDK
Online Access:Get full text
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Summary:Normally, cyclin interacts with cyclin-dependent kinase (CDK) to form a cyclin-CDK complex, which promotes cell cycle progression, whereas cyclin-dependent kinase inhibitor (CDKI) molecules inhibit the formation of cyclin- CDK complex, arresting cell cycle. Terminal erythropoiesis is closely coordinated with cell cycle exit, which is regulated by cyclins, CDKs, and CDKIs [1]. In the global transcriptome of human terminal erythropoiesis [2], p19INK4d is expressed highly, and its expression is significantly up-regulated during human terminal erythropoiesis. However, the roles of p19INK4d in terminal erythropoiesis are still unknown.
ISSN:1000-467X
1944-446X