Impact of obesity on kidneyfunction and blood pressurein children

In recent years, obesity has become an increasingly important epidemic health problem in children and adolescents. The prevalence of the overweight status in children grew from 5% to 11% from 1960 s to 1990 s. The epidemic of obesity has been paralleled by an increase in the incidence of chronic kid...

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Bibliographic Details
Published in:世界肾脏学杂志：英文版 2015 (2), p.223-229
Main Author: Wei Ding Wai W Cheung Robert H Mak
Format: Article
Language:English
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Summary:In recent years, obesity has become an increasingly important epidemic health problem in children and adolescents. The prevalence of the overweight status in children grew from 5% to 11% from 1960 s to 1990 s. The epidemic of obesity has been paralleled by an increase in the incidence of chronic kidney disease(CKD) and hypertension. Results of several studies have demonstrated that obesity and metabolic syndrome were independent predictors of renal injury. The pathophysiology of obesity related hypertension is complex, including activation of sympathetic nervous system, renin angiotensin aldosterone system, hyperinsulinemia and inflammation. These same mechanisms likely contribute to the development of increased blood pressure in children. This review summarizes the recent epidemiologic data linking obesity with CKD and hypertension in children, as well as the potential mechanisms.
ISSN:2220-6124
2220-6124