Expression of E2A in Mid-secretory Endometrium of Women Suffering from Recurrent Miscarriage

• Published in: 华中科技大学学报：医学英德文版 2017 (6), p.910-914
• Main Author: 尹智囊 丁锦丽 张怡 李赛姣 张艳 杨菁
• Format: Article
• Language: English
• ISSN: 1672-0733; 1993-1352

E2A is involved in promoting forkhead box P3(FOXP3) and retinoid-related orphan receptor gamma t(RORγt) gene transcription, which are pivotal transcription factors of T regulatory cells and Th17 cells, respectively. Little is known about the involvement of E2 A in pregnancy process. This study aimed to investigate the expression of E2 A, cytotoxic T-lymphocyte-associated protein 4(CTLA-4), and Foxp3 in luteal phase endometrium of women suffering recurrent miscarriage(RM)(n=21) and control group(n=11) by immunohistochemistry, with the Vectra? automated quantitative pathology imaging system for analysis. The percentage of E2 A+ cells and CTLA-4+ cells was significantly higher in the endometrium of women with RM than in the controls. There was positive correlation between E2 A and CTLA-4(r=0.523, P=0.002), E2 A and FOXP3(r=0.380, P=0.032), and FOXP3 and CTLA-4(r=0.625, P=0.000) in the mid-secretory phase of endometrium for all subjects. It was concluded that the abnormal expression of endometrial E2 A existed in mid-secretory endometrium of women with RM, and there was a positive correlation between E2 A and FOXP3, and E2 A and CTLA-4, suggesting the possible regulation role of E2 A involved in regulating endometrium receptivity.