Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian population

• Published in: The European respiratory journal 2016-12, Vol.48 (6), p.1602-1611
• Main Authors: Langhammer, Arnulf, Johannessen, Ane, Holmen, Turid L, Melbye, Hasse, Stanojevic, Sanja, Lund, May B, Melsom, Morten N, Bakke, Per, Quanjer, Philip H
• Format: Article
• Language: English
• Subjects: Adolescent; adolescents; Adult; adults; Age Factors; Aged; Aged, 80 and over; Child; Clinical medical disciplines: 750; Female; Forced Expiratory Volume; Healthy Volunteers; Humans; Klinisk medisinske fag: 750; Logistic Models; Lung - physiology; Lung diseases: 777; Lungesykdommer: 777; Male; Medical disciplines: 700; Medisinske Fag: 700; Middle Aged; Norway; Reference Values; Sex Factors; spirometry; Spirometry - methods; Tidal Volume; VDP; Young Adult
• ISSN: 0903-1936; 1399-3003; 1399-3003
• DOI: 10.1183/13993003.00443-2016

We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.Spirometry data collected in 30 239 subjects (51.7% females) aged 12-90 years in three population-based studies were converted to z-scores.We studied healthy non-smokers comprising 2438 adults (57.4% females) aged 20-90 years and 8725 (47.7% female) adolescents aged 12-19 years. The GLI-2012 prediction equations fitted the Norwegian data satisfactorily. Median±sd z-scores were respectively 0.02±1.03, 0.01±1.04 and -0.04±0.91 for forced expiratory volume in 1 s (FEV ), forced vital capacity (FVC) and FEV /FVC in males, and -0.01±1.02, 0.07±0.97 and -0.21±0.82 in females. The ECSC and Zapletal references significantly underestimated FEV and FVC. Stricter criteria of obstruction (FEV /FVC