Profiling of immune‐related gene expression in children with familial hypercholesterolaemia

Background Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial hypercholesterolaemia may serve as a human model to investigate the effect of...

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Bibliographic Details
Published in:Journal of internal medicine 2020-03, Vol.287 (3), p.310-321
Main Authors: Narverud, I., Christensen, J. J., Bakke, S. S., Ulven, S. M., Rundblad, A., Aukrust, P., Espevik, T., Bogsrud, M. P., Retterstøl, K., Ueland, T., Halvorsen, B., Holven, K. B.
Format: Article
Language:English
Subjects:
Adaptive immunity
Antigen presentation
Antigens
Apoptosis
Arteriosclerosis
Atherosclerosis
Cell differentiation
Children
Cholesterol
familial hypercholesterolaemia
Gene expression
Genes
Immunology
Inflammation
Interleukins
Leukocytes (mononuclear)
Low density lipoprotein
Lymphocytes
Lymphocytes B
Lymphocytes T
Medisinske Fag: 700
Peripheral blood mononuclear cells
Receptors
statins
Therapeutic applications
Therapy
Tumor necrosis factor
Tumors
VDP
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Summary:Background Innate and adaptive immune responses are pivotal in atherosclerosis, but their association with early‐stage atherosclerosis in humans is incompletely understood. In this regard, untreated children with familial hypercholesterolaemia may serve as a human model to investigate the effect of elevated low‐density lipoprotein (LDL)‐cholesterol. Objectives We aimed to study the immunological and inflammatory pathways involved in early atherosclerosis by examining mRNA molecules in peripheral blood mononuclear cells (PBMCs) from children with FH. Methods We analysed the level of 587 immune‐related mRNA molecules using state‐of‐the‐art Nanostring technology in PBMCs from children with (n = 30) and without (n = 21) FH, and from FH children before and after statin therapy (n = 10). Results 176 genes (30%) were differentially expressed between the FH and healthy children at P 
ISSN:0954-6820
1365-2796
1365-2796
DOI:10.1111/joim.13001