Functionalization of the Purine 8-Position via 8-Purinyl anions; Scopes and Limitations with Respect to Substituents at N9

The present thesis is focused on the methodology of lithiation-halogenation of 6-chloro-9-substituted purines and 9-substituted adenines via 8-purinyl anions. As an extension of this work, lithiation-halogenation of 7-allyl-6-chloro-7H-purine was also investigated.

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Bibliographic Details
Main Author: Lim, Fiona
Format: Dissertation
Language:English
Online Access:Request full text
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Summary:The present thesis is focused on the methodology of lithiation-halogenation of 6-chloro-9-substituted purines and 9-substituted adenines via 8-purinyl anions. As an extension of this work, lithiation-halogenation of 7-allyl-6-chloro-7H-purine was also investigated.