Melatonin expression in periodontitis and obesity: An experimental in‐vivo investigation

Background and Objective Melatonin deficiency has been associated with obesity and systemic inflammation. This study aims to evaluate whether melatonin could interfere with the mechanisms of co‐morbidity linking obesity and periodontitis. Material and Methods Twenty‐eight male Wistar rats were rando...

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Bibliographic Details
Published in:Journal of periodontal research 2018-10, Vol.53 (5), p.825-831
Main Authors: Virto, L., Haugen, H. J., Fernández‐Mateos, P., Cano, P., González, J., Jiménez‐Ortega, V., Esquifino, A. I., Sanz, M.
Format: Article
Language:English
Subjects:
Alveolar bone
Alveolar Bone Loss - diagnostic imaging
Animals
Bone loss
circadian rhythms
Computed tomography
Dental Health Surveys
Gingival index
Gum disease
High fat diet
Immunoassay
Inflammation
Male
Melatonin
Melatonin - blood
micro‐computed tomography
Morbidity
Obesity
Obesity - blood
Obesity - complications
Periodontitis
Periodontitis - blood
Periodontitis - complications
Periodontitis - diagnostic imaging
Random Allocation
Rats
Rats, Wistar
Rodents
X-Ray Microtomography
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Summary:Background and Objective Melatonin deficiency has been associated with obesity and systemic inflammation. This study aims to evaluate whether melatonin could interfere with the mechanisms of co‐morbidity linking obesity and periodontitis. Material and Methods Twenty‐eight male Wistar rats were randomly divided in 4 groups: control group (Con) (fed with standard diet); high‐fat diet group (HFD) (fed with a diet containing 35.2% fat); Con group with induced periodontitis (Con‐Perio) and HFD group with induced periodontitis (HFD‐Perio). To induce periodontitis, the method of oral gavages with Porphyromonas gingivalis ATCC W83K1 and Fusobacterium nucleatum DMSZ 20482 was used. Circulating melatonin levels were analyzed by multiplex immunoassays. Periodontitis was assessed by alveolar bone loss (micro‐computed tomography and histology) and by surrogate inflammatory outcomes (periodontal pocket depth, modified gingival index and plaque dental index). Results Plasma melatonin levels were significantly decreased (P 
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12571