OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

Abstract OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosp...

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Bibliographic Details
Published in:Hormone and metabolic research 2017-04, Vol.49 (4), p.276-285
Main Authors: Chu, Dinh-Toi, Tao, Yang, Taskén, Kjetil
Format: Article
Language:English
Subjects:
Adipocytes, Brown - metabolism
Animals
Cyclic AMP-Dependent Protein Kinases - metabolism
GTP Phosphohydrolases - metabolism
Humans
Lipolysis - physiology
Perilipin-1 - metabolism
Review
Thermogenesis - physiology
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Summary:Abstract OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.
ISSN:0018-5043
1439-4286
DOI:10.1055/s-0043-100384