Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), an...

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Published in:Dementia and geriatric cognitive disorders 2018-01, Vol.46 (5-6), p.346-357
Main Authors: Halaas, Nathalie Bodd, Blennow, Kaj, Idland, Ane-Victoria, Wyller, Torgeir Bruun, Ræder, Johan, Frihagen, Frede, Staff, Anne Cathrine, Zetterberg, Henrik, Watne, Leiv Otto
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Complications and side effects
Cytoplasmic filaments
Delirium
Demographic aspects
Development and progression
Diagnosis
Hip fractures
Measurement
Neurosciences
Neurovetenskaper
Original Research Article
Risk factors
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Summary:Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Delirium was diagnosed with the Confusion Assessment Method. Results: Median serum NFL (pg/mL) was elevated in delirium in hip fracture patients (94 vs. 54 pre- and 135 vs. 92 postoperatively, both p < 0.001). Median CSF NFL tended to be higher in hip fracture patients with delirium (1,804 vs. 1,636, p = 0.074). Serum and CSF NFL were positively correlated (ρ = 0.56, p < 0.001). Conclusion: Our findings support an association between neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.
ISSN:1420-8008
1421-9824
1421-9824
DOI:10.1159/000494754