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Crosstalk of endoplasmic reticulum exit sites and cellular signaling

The synthesis, quality control, and trafficking of a third of the eukaryotic proteome takes place at the endoplasmic reticulum (ER), which is the largest cellular organelle. Thus, biosynthetic trafficking from the ER, although constitutive, has to be tightly controlled. Increasing evidence indicates...

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Bibliographic Details
Published in:FEBS letters 2019-09, Vol.593 (17), p.2280-2288
Main Authors: Centonze, Federica G., Farhan, Hesso
Format: Article
Language:English
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Summary:The synthesis, quality control, and trafficking of a third of the eukaryotic proteome takes place at the endoplasmic reticulum (ER), which is the largest cellular organelle. Thus, biosynthetic trafficking from the ER, although constitutive, has to be tightly controlled. Increasing evidence indicates that the ER acts as a platform that initiates signaling events. In this review, we focus on signaling pathways that target components of the ER export machinery to regulate protein export. In addition, we discuss how signaling generated at the ER regulates various homeostatic cellular processes such as cell growth and proliferation, and how the deregulation thereof is involved in disease.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.13569