The NCCN Criterion "Young Age at Onset" Alone is Not an Indicator of Hereditary Breast Cancer in Iranian Population

Because the contribution of genetic factors to the burden of breast cancer is not well investigated in Iran, we aimed to examine the prevalence of mutations in breast cancer susceptibility genes, and , and to investigate the predictive potential of hereditary breast cancer risk criteria for genetic...

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Bibliographic Details
Published in:Cancer prevention research (Philadelphia, Pa.) Pa.), 2019-11, Vol.12 (11), p.763-770
Main Authors: Ebrahimi, Elmira, Sellars, Erin, Shirkoohi, Reza, Harirchi, Iraj, Ghiasvand, Reza, Mohebbi, Elham, Zendehdel, Kazem, Akbari, Mohammad R
Format: Article
Language:English
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Summary:Because the contribution of genetic factors to the burden of breast cancer is not well investigated in Iran, we aimed to examine the prevalence of mutations in breast cancer susceptibility genes, and , and to investigate the predictive potential of hereditary breast cancer risk criteria for genetic testing in Iranian population. Next-generation sequencing was conducted on a population consisting of 299 and 125 patients with breast cancer, with and without hereditary cancer risk criteria for genetic testing, respectively. The pathogenic mutation frequency rate was 10.7% in patients with hereditary cancer criteria versus 1.6% in no criteria group ( = 0.0017). None of the 107 tested patients with only young age at onset (
ISSN:1940-6207
1940-6215
DOI:10.1158/1940-6207.CAPR-19-0056