The case for allele‐specific recognition by the TCR

There is a sharp difference in how one views TCR structure–function–behaviour dependent on whether its recognition of major histocompatibility complex‐encoded restriction elements (R) is germline selected or somatically generated. The generally accepted or Standard model is built on the assumption t...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2019-08, Vol.90 (2), p.e12790-n/a
Main Authors: Cohn, Melvin, Anderson, Colin C., Dembic, Zlatko
Format: Article
Language:English
Subjects:
Alleles
Major histocompatibility complex
MHC < molecules
Structure-function relationships
T cell receptors < molecules
thymus < tissues
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Summary:There is a sharp difference in how one views TCR structure–function–behaviour dependent on whether its recognition of major histocompatibility complex‐encoded restriction elements (R) is germline selected or somatically generated. The generally accepted or Standard model is built on the assumption that recognition of R is by the V regions of the αβ TCR, which is not driven by allele specificity, whereas the competing model posits that recognition of R is allele‐specific. The establishing of allele‐specific recognition of R by the TCR would rule out the Standard model and clear the road to a consideration of a competing construct, the Tritope model. Here, the case for allele‐specific recognition (germline selected) is detailed making it obvious that the Standard model is untenable.
ISSN:0300-9475
1365-3083
DOI:10.1111/sji.12790