Primary adrenal lymphoma as a cause of adrenal insufficiency, a report of two cases

Primary adrenal lymphoma (PAL) is a rare cause of adrenal insufficiency. More than 90% is of B-cell origin. The condition is bilateral in up to 75% of cases, with adrenal insufficiency in two of three patients. We report two cases of adrenal insufficiency presenting at the age of 70 and 79 years, re...

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Published in:Endocrinology, diabetes & metabolism diabetes & metabolism, 2020
Main Authors: Grønning, Kaja, Sharma, Archana, Mastroianni, Maria Adele, Karlsson, Bo Daniel, Husebye, Eystein Sverre, Løvås, Kristian, Nermoen, Ingrid
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container_title Endocrinology, diabetes & metabolism
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creator Grønning, Kaja
Sharma, Archana
Mastroianni, Maria Adele
Karlsson, Bo Daniel
Husebye, Eystein Sverre
Løvås, Kristian
Nermoen, Ingrid
description Primary adrenal lymphoma (PAL) is a rare cause of adrenal insufficiency. More than 90% is of B-cell origin. The condition is bilateral in up to 75% of cases, with adrenal insufficiency in two of three patients. We report two cases of adrenal insufficiency presenting at the age of 70 and 79 years, respectively. Both patients had negative 21-hydroxylase antibodies with bilateral adrenal lesions on CT. Biopsy showed B-cell lymphoma. One of the patients experienced intermittent disease regression on replacement dosage of glucocorticoids.
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title Primary adrenal lymphoma as a cause of adrenal insufficiency, a report of two cases
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