Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention

Morbid obesity is a risk factor for cardiovascular disease. The relative effects of Roux-en-Y gastric bypass surgery (GBS) and intensive lifestyle intervention (ILI) on subclinical myocardial injury, the activity of the cardiac natriuretic system, and systemic inflammation remain unclear. In a 59-we...

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Bibliographic Details
Published in:Clinical biochemistry 2020-12, Vol.86, p.36-44
Main Authors: Aakre, Kristin M., Omland, Torbjørn, Nordstrand, Njord, Gjevestad, Espen S., Holven, Kirsten B., Lyngbakken, Magnus N., Hjelmesæth, Jøran
Format: Article
Language:English
Subjects:
Adult
C-Reactive Protein - metabolism
Cardiovascular risk
CRP
Diet, Reducing
Exercise
Female
Gastric Bypass
Health Education
Heart Injuries - complications
Humans
Life Style
Male
Middle Aged
Myocarditis - complications
Natriuretic Peptides - blood
NT-proBNP
Obesity, Morbid - complications
Obesity, Morbid - diet therapy
Obesity, Morbid - surgery
Roux-en-Y gastric bypass
Troponin
Troponin I - blood
Troponin T - blood
Weight Loss
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Summary:Morbid obesity is a risk factor for cardiovascular disease. The relative effects of Roux-en-Y gastric bypass surgery (GBS) and intensive lifestyle intervention (ILI) on subclinical myocardial injury, the activity of the cardiac natriuretic system, and systemic inflammation remain unclear. In a 59-week non-randomized clinical trial that included 131 patients with morbid obesity, we compared the effects ofGBS and ILI on concentrations of cardiac troponin T (cTnT) and I (cTnI), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and C-reactive protein (CRP). In the GBS and ILI group, median body mass index (BMI) was reduced by 14.4 kg/m2 versus 3.9 kg/m2, respectively (p value 
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2020.09.006