High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study

To assess if cardiac troponins can improve diagnostics of acute heart failure (AHF) and provide prognostic information in patients with acute dyspnea. We measured cardiac troponin T with a high-sensitivity assay (hs-cTnT) in 314 patients hospitalized with acute dyspnea. The index diagnosis was adjud...

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Bibliographic Details
Published in:Clinical biochemistry 2021-02, Vol.88, p.30-36
Main Authors: Berge, Kristian, Lyngbakken, Magnus Nakrem, Myhre, Peder Langeland, Brynildsen, Jon, Røysland, Ragnhild, Strand, Heidi, Christensen, Geir, Høiseth, Arne Didrik, Omland, Torbjørn, Røsjø, Helge
Format: Article
Language:English
Subjects:
Biomarker
Cardiovascular
Heart failure
HFpEF
Troponin
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Summary:To assess if cardiac troponins can improve diagnostics of acute heart failure (AHF) and provide prognostic information in patients with acute dyspnea. We measured cardiac troponin T with a high-sensitivity assay (hs-cTnT) in 314 patients hospitalized with acute dyspnea. The index diagnosis was adjudicated and AHF patients were stratified into AHF with reduced or preserved ejection fraction (HFrEF/HFpEF). The prognostic and diagnostic merit of hs-cTnT was compared to the merit of N-terminal pro-B-type natriuretic peptide (NT-proBNP). In the total population, median age was 73 (quartile [Q] 1–3 63–81) years and 48% were women. One-hundred-forty-three patients were categorized as AHF (46%) and these patients had higher hs-cTnT concentrations than patients with non-AHF-related dyspnea: median 38 (Q1-3 22–75) vs. 13 (4–25) ng/L; p 
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2020.11.009