Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay

Background: Circulating secretoneurin (SN) concentrations, as measured by established radioimmunoassay (RIA), risk stratify patients with cardiovascular disease. We now report data for a recently developed research-use-only SN enzyme-linked immunosorbent assay (ELISA) in patients with suspected acut...

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Bibliographic Details
Published in:Cardiology 2021, Vol.146 (5), p.566-574
Main Authors: Myhre, Peder L., Ottesen, Anett H., Faaren, Arne L., Tveit, Sjur H., Springett, Jon, Pyylampi, Johanna, Stridsberg, Mats, Christensen, Geir, Høiseth, Arne Didrik, Omland, Torbjørn, Røsjø, Helge
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - diagnosis
Cardiovascular Biomarkers: Research Article
Enzyme-Linked Immunosorbent Assay
Humans
Neuropeptides - analysis
Radioimmunoassay
Secretogranin II - analysis
Secretoneurin
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Summary:Background: Circulating secretoneurin (SN) concentrations, as measured by established radioimmunoassay (RIA), risk stratify patients with cardiovascular disease. We now report data for a recently developed research-use-only SN enzyme-linked immunosorbent assay (ELISA) in patients with suspected acute coronary syndrome (ACS). Methods: SN ELISA was developed according to industry standards and tested in 401 unselected chest pain patients. Blood samples were drawn
ISSN:0008-6312
1421-9751
1421-9751
DOI:10.1159/000517444