A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Background and Aims Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal microbiota are less consistent. We aimed to use a large colonoscopy cohort to investigate key knowledge gaps, including the role of gut mic...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 2022
Main Authors: Hole, Mikal Jacob, Jørgensen, Kristin Kaasen, Holm, Kristian, Braadland, Peder Rustøen, Meyer-Myklestad, Malin Holm, Medhus, Asle Wilhelm, Reikvam, Dag Henrik, Götz, Alexandra, Grzyb, Krzysztof, Boberg, Kirsten Muri, Karlsen, Tom Hemming, Kummen, Martin, Hov, Johannes Espolin Roksund
Format: Article
Language:Norwegian
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Summary:Background and Aims Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal microbiota are less consistent. We aimed to use a large colonoscopy cohort to investigate key knowledge gaps, including the role of gut microbiota in PSC with inflammatory bowel disease (IBD), the effect of liver transplantation (LT), and whether recurrent PSC (rPSC) may be used to define consistent microbiota features in PSC irrespective of LT. Approach and Results We included 84 PSC and 51 liver transplanted PSC patients (PSC-LT) and 40 healthy controls (HCs) and performed sequencing of the 16S ribosomal RNA gene (V3–V4) from ileocolonic biopsies. Intraindividual microbial diversity was reduced in both PSC and PSC-LT versus HCs. An expansion of Proteobacteria was more pronounced in PSC-LT (up to 19% relative abundance) than in PSC (up to 11%) and HCs (up to 8%; QFDR 
ISSN:0270-9139
1527-3350