No association of tobacco use and disease activity in multiple sclerosis

Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally included in a randomized placebo-controlled trial of omega-3 fatty acids in M...

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Main Authors: Kvistad, Silje, Myhr, Kjell-Morten, Holmøy, Trygve, Saltyte Benth, Jurate, Løken-Amsrud, Kristin Ingeleiv, Wergeland, Stig, Beiske, Antonie Giæver, Bjerve, Kristian S, Hovdal, Harald Olav, Lilleås, Finn, Midgard, Rune, Pedersen, Tom, Bakke, Søren Jacob, Torkildsen, Øivind
Format: Article
Language:English
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Summary:Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally included in a randomized placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS Study). Serum levels of cotinine (biomarker of tobacco use) were analyzed at baseline and every 6 months for 2 years. MRI activity was assessed at baseline and monthly for 9 months and after 12 and 24 months. Results: Fifty-three patients (61%) had serum cotinine levels ≥85 nmol/L on ≥60% of the measurements and were considered tobacco users and 34 (39%) had cotinine levels