Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. Methods: A total of 45 risk factors with genetic data in European ancestry and...

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Main Authors: Zheng, Jie, Zhang, Yuemiao, Rasheed, Humaira, Walker, Venexia M, Sugawara, Yuka, Li, Jiachen, Leng, Yue, Elsworth, Benjamin, Wootton, Robyn E, Fang, Si, Yang, Qian, Burgess, Stephen, Haycock, Philip C, Borges, Maria Carolina, Carnegie, Rebecca, Cho, Yoonsu, Howell, Amy, Robinson, Jamie, Thomas, Laurent, Brumpton, Ben Michael, Hveem, Kristian, Hallan, Stein, Franceschini, Nora, Morris, Andrew P, Köttgen, Anna, Pattaro, Cristian, Wuttke, Matthias, Yamamoto, Masayuki, Kashihara, Naoki, Akiyama, Masato, Kanai, Masahiro, Matsuda, Koichi, Kamatani, Yoichiro, Okada, Yukinori, Walters, Robin, Millwood, Iona Y, Chen, Zhengming, Smith, George Davey, Barbour, Sean, Yu, Canqing, Åsvold, Bjørn Olav, Zhang, Hong, Gaunt, Tom R
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Language:English
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Summary:Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. Methods: A total of 45 risk factors with genetic data in European ancestry and 17 risk factors in East Asian participants were identified as exposures from PubMed. We defined the CKD by clinical diagnosis or by estimated glomerular filtration rate of 25 kg/m2. Conclusions: Eight cardiometabolic risk factors showed causal effects on CKD in Europeans and three of them showed causality in East Asians, providing insights into the design of future interventions to reduce the burden of CKD.