Body mass index trajectories and associations with cognitive decline in people with Lewy body dementia and Alzheimer's disease

Background and Aims In older adults with dementia, low body mass index (BMI) is associated with higher mortality and other adverse health outcomes. BMI or nutritional status trajectories from diagnosis have not yet been well described in dementia, especially in people with Lewy body dementia (LBD);...

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Bibliographic Details
Main Authors: Borda, Miguel Germán, Jaramillo-Jiménez, Alberto, Melvær, Giil Lasse, Tovar-Rios, Diego Alejandro, Sønnesyn, Hogne, Aarsland, Dag
Format: Article
Language:English
Subjects:
BMI
demens
demens med Lewy-legemer
kognitiv funksjon
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Summary:Background and Aims In older adults with dementia, low body mass index (BMI) is associated with higher mortality and other adverse health outcomes. BMI or nutritional status trajectories from diagnosis have not yet been well described in dementia, especially in people with Lewy body dementia (LBD); a group that has a poorer prognosis. With this study, we aimed to evaluate the BMI trajectory in people diagnosed with mild LBD and Alzheimer's disease (AD). Methods The Dementia Study of Western Norway is a cohort study with annual assessments. Five-year measurements of BMI from 196 patients (LBD = 85 and AD = 111) diagnosed with mild dementia were analyzed using adjusted linear mixed-effects models. Results There were no differences between LBD and AD in baseline BMI, age, or mini-mental status examination (MMSE). During the follow-up, we observed a significant decrease in BMI in the LBD group across the study period (estimation [Est.]: −0.63, SE: 0.14; p