GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P...

Full description

Saved in:
Bibliographic Details
Main Authors: Eriksson, Daniel, Røyrvik, Ellen Christine, Aranda-Guillen, Maribel, Berger, Amund Holte, Landegren, Nils, Artaza, Haydee, Hallgren, Åsa, Grytaas, Marianne, Strøm, Sara, Bratland, Eirik, Botusan, Ileana, Oftedal, Bergithe Eikeland, Breivik, Lars Ertesvåg, Vaudel, Marc, Helgeland, Øyvind, Falorni, Alberto, Jørgensen, Anders Palmstrøm, Hulting, Anna-Lena, Svartberg, Johan, Ekwall, Olov, Fougner, Kristian J, Wahlberg, Jeanette, Nedrebø, Bjørn Gunnar, Dahlqvist, Per, Study group, Norwegian Addison Registry, Study Group, Swedish Addison Registry, Knappskog, Per Morten, Wolff, Anette Susanne Bøe, Bensing, Sophie, Johansson, Stefan, Kämpe, Olof, Husebye, Eystein Sverre
Format: Article
Language:English
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P