HPV self-sampling among long-term non-attenders to cervical cancer screening in Norway: a pragmatic randomised controlled trial

Background Cervical cancer screening participation is suboptimal in most settings. We assessed whether human papillomavirus (HPV) self-sampling may increase screening participation among long-term non-attenders in Norway. Methods A pragmatic randomised controlled trial with participation as the prim...

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Main Authors: Aasbø, Gunvor, Trope, Ameli, Nygård, Mari, Christiansen, Irene Kraus, Baasland, Ingrid, Iversen, Grete Alræk, Munk, Ane Cecilie Dæhli, Christiansen, Marit Halonen, Presthus, Gro Kummeneje, Undem, Karina, Bjørge, Tone, Castle, Philip E, Hansen, Bo Lars Thorvald Terning
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Language:English
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Summary:Background Cervical cancer screening participation is suboptimal in most settings. We assessed whether human papillomavirus (HPV) self-sampling may increase screening participation among long-term non-attenders in Norway. Methods A pragmatic randomised controlled trial with participation as the primary outcome was initiated in the national cervical screening programme in March 2019. A random sample of 6000 women aged 35–69 years who had not attended screening for at least 10 years were randomised 1:1:1 to receive either (i) a reminder to attend regular screening (control), (ii) an offer to order a self-sampling kit (opt-in) for HPV testing or (iii) a self-sampling kit unsolicited (send-to-all) for HPV testing. Results Total participation was 4.8%, 17.0% and 27.7% among control, opt-in and send-to-all (P 
ISSN:1816-1826