Association of Genetically Predicted Insomnia with Risk of Sepsis: A Mendelian Randomization Study

Importance Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. To further understand the potential causal association between insomnia and...

Full description

Saved in:
Bibliographic Details
Main Authors: Thorkildsen, Marianne Thorkildsen, Gustad, Lise Tuset, Mohus, Randi Marie, Burgess, Stephen, Nilsen, Tom Ivar Lund, Damås, Jan Kristian, Rogne, Tormod
Format: Article
Language:English
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Importance Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. To further understand the potential causal association between insomnia and sepsis risk, a 2-sample Mendelian randomization (MR) approach should be explored. Objective To evaluate whether genetically predicted insomnia is associated with risk of sepsis. Design, Setting, and Participants Two-sample MR was performed to estimate the association between genetically predicted insomnia and sepsis risk. Data were obtained from a genome-wide association study identifying 555 independent genetic variants (R2 
ISSN:1061-1065