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Synergistic upregulation of NONO and PSPC 1 regulates Sertoli cell response to MEHP via modulation of ALDH 1A1 signaling
Members of the Drosophila behavior/human splicing protein family, including splicing factor proline/glutamine rich ( SFPQ ), non‐ POU domain‐containing octamer‐binding protein ( NONO ), and paraspeckle protein component 1 ( PSPC 1), are abundantly expressed in testicular Sertoli cells ( SC s), but t...
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Published in: | FEBS letters 2017-03, Vol.591 (6), p.914-923 |
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container_title | FEBS letters |
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creator | Dong, Bing‐wei Jin, Xiao‐hang Yan, Chang‐you Yang, Tian Cai, Guo‐qing Lu, Jian |
description | Members of the
Drosophila
behavior/human splicing protein family, including splicing factor proline/glutamine rich (
SFPQ
), non‐
POU
domain‐containing octamer‐binding protein (
NONO
), and paraspeckle protein component 1 (
PSPC
1), are abundantly expressed in testicular Sertoli cells (
SC
s), but their roles remain obscure. Here, we show that treatment with mono‐(2‐ethylhexyl) phthalate (
MEHP
), a well‐known
SC
toxicant, selectively stimulates the expression levels of
NONO
and
PSPC
1. Simultaneous inhibition of
NONO
and
PSPC
1 expression in
SC
s enhances
MEHP
‐induced oxidative stress and potentiates
SC
death. Mechanistically,
NONO
and
PSPC
1 transcriptionally activate aldehyde dehydrogenase 1 (
Aldh1a1
), by synergistically binding to the distinct
CCGGAGTC
sequence in the
Aldh1a1
promoter. Together, the
NONO
/
PSPC
1‐
ALDH
1A1 cascade may serve as an indispensable defense mechanism against
MEHP
insult in
SC
s. |
doi_str_mv | 10.1002/1873-3468.12568 |
format | article |
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Drosophila
behavior/human splicing protein family, including splicing factor proline/glutamine rich (
SFPQ
), non‐
POU
domain‐containing octamer‐binding protein (
NONO
), and paraspeckle protein component 1 (
PSPC
1), are abundantly expressed in testicular Sertoli cells (
SC
s), but their roles remain obscure. Here, we show that treatment with mono‐(2‐ethylhexyl) phthalate (
MEHP
), a well‐known
SC
toxicant, selectively stimulates the expression levels of
NONO
and
PSPC
1. Simultaneous inhibition of
NONO
and
PSPC
1 expression in
SC
s enhances
MEHP
‐induced oxidative stress and potentiates
SC
death. Mechanistically,
NONO
and
PSPC
1 transcriptionally activate aldehyde dehydrogenase 1 (
Aldh1a1
), by synergistically binding to the distinct
CCGGAGTC
sequence in the
Aldh1a1
promoter. Together, the
NONO
/
PSPC
1‐
ALDH
1A1 cascade may serve as an indispensable defense mechanism against
MEHP
insult in
SC
s.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.12568</identifier><language>eng</language><ispartof>FEBS letters, 2017-03, Vol.591 (6), p.914-923</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c868-b89213148011a6df2aa1b57721886af1f0ca60030aa7a48152a5a54cc9f7af923</citedby><cites>FETCH-LOGICAL-c868-b89213148011a6df2aa1b57721886af1f0ca60030aa7a48152a5a54cc9f7af923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Dong, Bing‐wei</creatorcontrib><creatorcontrib>Jin, Xiao‐hang</creatorcontrib><creatorcontrib>Yan, Chang‐you</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Cai, Guo‐qing</creatorcontrib><creatorcontrib>Lu, Jian</creatorcontrib><title>Synergistic upregulation of NONO and PSPC 1 regulates Sertoli cell response to MEHP via modulation of ALDH 1A1 signaling</title><title>FEBS letters</title><description>Members of the
Drosophila
behavior/human splicing protein family, including splicing factor proline/glutamine rich (
SFPQ
), non‐
POU
domain‐containing octamer‐binding protein (
NONO
), and paraspeckle protein component 1 (
PSPC
1), are abundantly expressed in testicular Sertoli cells (
SC
s), but their roles remain obscure. Here, we show that treatment with mono‐(2‐ethylhexyl) phthalate (
MEHP
), a well‐known
SC
toxicant, selectively stimulates the expression levels of
NONO
and
PSPC
1. Simultaneous inhibition of
NONO
and
PSPC
1 expression in
SC
s enhances
MEHP
‐induced oxidative stress and potentiates
SC
death. Mechanistically,
NONO
and
PSPC
1 transcriptionally activate aldehyde dehydrogenase 1 (
Aldh1a1
), by synergistically binding to the distinct
CCGGAGTC
sequence in the
Aldh1a1
promoter. Together, the
NONO
/
PSPC
1‐
ALDH
1A1 cascade may serve as an indispensable defense mechanism against
MEHP
insult in
SC
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Drosophila
behavior/human splicing protein family, including splicing factor proline/glutamine rich (
SFPQ
), non‐
POU
domain‐containing octamer‐binding protein (
NONO
), and paraspeckle protein component 1 (
PSPC
1), are abundantly expressed in testicular Sertoli cells (
SC
s), but their roles remain obscure. Here, we show that treatment with mono‐(2‐ethylhexyl) phthalate (
MEHP
), a well‐known
SC
toxicant, selectively stimulates the expression levels of
NONO
and
PSPC
1. Simultaneous inhibition of
NONO
and
PSPC
1 expression in
SC
s enhances
MEHP
‐induced oxidative stress and potentiates
SC
death. Mechanistically,
NONO
and
PSPC
1 transcriptionally activate aldehyde dehydrogenase 1 (
Aldh1a1
), by synergistically binding to the distinct
CCGGAGTC
sequence in the
Aldh1a1
promoter. Together, the
NONO
/
PSPC
1‐
ALDH
1A1 cascade may serve as an indispensable defense mechanism against
MEHP
insult in
SC
s.</abstract><doi>10.1002/1873-3468.12568</doi><tpages>10</tpages></addata></record> |
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issn | 0014-5793 1873-3468 |
language | eng |
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source | Wiley-Blackwell Read & Publish Collection |
title | Synergistic upregulation of NONO and PSPC 1 regulates Sertoli cell response to MEHP via modulation of ALDH 1A1 signaling |
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