Recent Advances in Engineering Bioinks for 3D Bioprinting

• Published in: Advanced engineering materials 2023-10, Vol.25 (19), p.n/a
• Main Authors: Wang, Haonan, Bi, Shihao, Shi, Bingbing, Ma, Junchi, Lv, Xiangwei, Qiu, Jianfeng, Wei, Yunyun
• Format: Article
• Language: English
• Subjects: 3D bioprinting; bioink; biomaterial; biomolecules; tissue engineering
• ISSN: 1438-1656; 1527-2648
• DOI: 10.1002/adem.202300648

The 3D bioprinting can controllably deposit bioink containing cells and fabricate complex bionic tissue structures in a fast and scalable way, which is expected to completely change the scenario of clinical organ transplantation. Bioprinting holds broad application prospect in tissue engineering, life sciences, and clinical medicine. In the process of 3D bioprinting, bioink, as the carrier of cells and bioactive substances, influences cell activity and accuracy of organ structure after printing. To better understand and design bioink, in this review, the concept, development, and basic composition of bioink are introduced, while focusing on the advantages and disadvantages of various biomaterials, and the use of common cells and biomolecules that constitute bioink. In addition, the properties and applications of various stimuli‐responsive smart materials for 4D bioprinting are mentioned. The challenges and development trends of bioink are also summarized. The 3D bioprinting can fabricate complex bionic structures via precisely deposit bioink. To better design bioink, in this review common components of bioink, containing biomaterials, cells, biomolecules, and functional particles, are introduced, while focusing on the advantages and disadvantages of various biomaterials. Additionally, the development trends of various stimuli‐responsive bioinks are also presented.