Targeted Chemotherapy: Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide and Acid-Responsive Antitumor Drug (Adv. Funct. Mater. 34/2014)

On page 5348, N. Komatsu, X. Chen, and colleagues demonstrate multifunctional anticancer prodrug consisting of nanodiamond core, polyglycerol coating, targeting peptide and platinum‐based drugs. The resulting good aqueous solubility, stealth nature, and targeting property enable the nanodiamond‐base...

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Published in:Advanced functional materials 2014-09, Vol.24 (34), p.5310-5310
Main Authors: Zhao, Li, Xu, Yong-Hong, Qin, Hongmei, Abe, Shigeaki, Akasaka, Tsukasa, Chano, Tokuhiro, Watari, Fumio, Kimura, Takahide, Komatsu, Naoki, Chen, Xiao
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Language:English
Subjects:
cisplatin
drug release
nanodiamonds
polyglycerol
targeted chemotherapy
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container_end_page 5310
container_issue 34
container_start_page 5310
container_title Advanced functional materials
container_volume 24
creator Zhao, Li
Xu, Yong-Hong
Qin, Hongmei
Abe, Shigeaki
Akasaka, Tsukasa
Chano, Tokuhiro
Watari, Fumio
Kimura, Takahide
Komatsu, Naoki
Chen, Xiao
description On page 5348, N. Komatsu, X. Chen, and colleagues demonstrate multifunctional anticancer prodrug consisting of nanodiamond core, polyglycerol coating, targeting peptide and platinum‐based drugs. The resulting good aqueous solubility, stealth nature, and targeting property enable the nanodiamond‐based prodrug to be taken up selectively by cancer cells overexpressing αvβ3 integrin and to cause the selective cell death through acid‐responsive drug release.
doi_str_mv 10.1002/adfm.201470225
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subjects cisplatin
drug release
nanodiamonds
polyglycerol
targeted chemotherapy
title Targeted Chemotherapy: Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide and Acid-Responsive Antitumor Drug (Adv. Funct. Mater. 34/2014)
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