Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO 2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy

• Published in: Advanced healthcare materials 2020-01, Vol.9 (2), p.e1901528
• Main Authors: Zhang, Yiyi, Lv, Fan, Cheng, Yaru, Yuan, Zhipeng, Yang, Fan, Liu, Conghui, Cao, Yu, Zhang, Kai, Lu, Huiting, Zada, Shah, Guo, Shaojun, Dong, Haifeng, Zhang, Xueji
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Female; Gold - chemistry; Humans; Hydrogen Peroxide - chemistry; Manganese Compounds - chemistry; MCF-7 Cells; Metal Nanoparticles - chemistry; Mice, Inbred BALB C; Multifunctional Nanoparticles; Oxides - chemistry; Oxygen - pharmacokinetics; Palladium - chemistry; Photochemotherapy - methods; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Photothermal Therapy - methods; Theranostic Nanomedicine - methods; Tumor Hypoxia - drug effects; Tumor Microenvironment; Xenograft Model Antitumor Assays
• ISSN: 2192-2640; 2192-2659
• DOI: 10.1002/adhm.201901528

Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO nanoplates (H-MnO ) are demonstrated for achieving not only nucleus-targeted NIR-II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic therapy (PDT). The Pd@Au nanoplates present a photothermal conversion efficiency (PTCE) as high as 56.9%, superior to those PTAs activated in the NIR-II region such as Cu S nanoparticles (37%), Cu BiS nanorods (40.7%), and Au/Cu S nanocrystals (43.2%). They further functionalize with transactivator of transcription (TAT) moiety for cell nuclear-targeting and biodegradable hollow mesoporous MnO (≈100 nm) loaded with photosensitizer Ce6 (TAT-Pd@Au/Ce6/PAH/H-MnO ) to construct a hierarchical targeting nanoplatform. The as-made TAT-Pd@Au/Ce6/PAH/H-MnO demonstrates good premature renal clearance escape ability and increased tumor tissue accumulation. It can be degraded in acidic TME and generate O by reacting to endogenous H O to relieve the hypoxia for enhanced PDT, while the released small TAT-Pd@Au nanoplates can effectively enter into the nucleus to mediate PTT. As a result, a remarkable therapeutic effect is achieved owing to the synergistic PTT/PDT therapy. This hierarchical targeting, TME-responsive, cytoplasm hypoxia relief PDT, and nuclear NIR-II PTT synergistic therapy can pave a new avenue for nanomaterials-based cancer therapy.