Cancer Immunotherapy: Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres (Adv. Healthcare Mater. 9/2019)

In article number 1900039, Yongbin Mou, Zhaogang Teng, and co‐workers show that iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs) with core‐shell structure, high surface area, large mesopores and huge pore volume can initiate DC‐based T cell activation and tumor‐associat...

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Bibliographic Details
Published in:Advanced healthcare materials 2019-05, Vol.8 (9), p.n/a
Main Authors: Chen, Lin, Ma, Xiaobo, Dang, Meng, Dong, Heng, Hu, Hongming, Su, Xiaodan, Liu, Wenfei, Wang, Qing, Mou, Yongbin, Teng, Zhaogang
Format: Article
Language:English
Subjects:
cancer immunotherapy
iron oxide
macrophage polarization
mesoporous organosilica
T cell activation
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Summary:In article number 1900039, Yongbin Mou, Zhaogang Teng, and co‐workers show that iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs) with core‐shell structure, high surface area, large mesopores and huge pore volume can initiate DC‐based T cell activation and tumor‐associated macrophage (TAM) polarization simultaneously. The combined T cell activation and macrophage polarization strategy based on the IO‐LPMONs elicits remarkable combined antitumor effects. This study demonstrates that the new‐synthesized IO‐LPMONs hold excellent potential as an immune modulator for cancer immunotherapy.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201970041