Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024)

Supramolecular Hydrogels In article 2302607, Motomu Tanaka and co‐workers show that reversible host‐guest crosslinks in supramolecular hydrogels enable on‐demand mechanical stimulation of human mesenchymal stem cells. A subtle change in substrate stiffness across the critical threshold turns on and...

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Bibliographic Details
Published in:Advanced healthcare materials 2024-04, Vol.13 (10), p.n/a
Main Authors: Linke, Philipp, Munding, Natalie, Kimmle, Esther, Kaufmann, Stefan, Hayashi, Kentaro, Nakahata, Masaki, Takashima, Yoshinori, Sano, Masaki, Bastmeyer, Martin, Holstein, Thomas, Dietrich, Sascha, Müller‐Tidow, Carsten, Harada, Akira, Ho, Anthony D., Tanaka, Motomu
Format: Article
Language:English
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Summary:Supramolecular Hydrogels In article 2302607, Motomu Tanaka and co‐workers show that reversible host‐guest crosslinks in supramolecular hydrogels enable on‐demand mechanical stimulation of human mesenchymal stem cells. A subtle change in substrate stiffness across the critical threshold turns on and off cell traction force and YAP/TAZ signaling, followed by shape adaptation. A frequent mechanical stress beyond the critical frequency suppresses the stem cell proliferation with no loss of multipotency.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202470071