Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024)

Supramolecular Hydrogels In article 2302607, Motomu Tanaka and co‐workers show that reversible host‐guest crosslinks in supramolecular hydrogels enable on‐demand mechanical stimulation of human mesenchymal stem cells. A subtle change in substrate stiffness across the critical threshold turns on and...

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Published in:Advanced healthcare materials 2024-04, Vol.13 (10), p.n/a
Main Authors: Linke, Philipp, Munding, Natalie, Kimmle, Esther, Kaufmann, Stefan, Hayashi, Kentaro, Nakahata, Masaki, Takashima, Yoshinori, Sano, Masaki, Bastmeyer, Martin, Holstein, Thomas, Dietrich, Sascha, Müller‐Tidow, Carsten, Harada, Akira, Ho, Anthony D., Tanaka, Motomu
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container_issue 10
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container_title Advanced healthcare materials
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creator Linke, Philipp
Munding, Natalie
Kimmle, Esther
Kaufmann, Stefan
Hayashi, Kentaro
Nakahata, Masaki
Takashima, Yoshinori
Sano, Masaki
Bastmeyer, Martin
Holstein, Thomas
Dietrich, Sascha
Müller‐Tidow, Carsten
Harada, Akira
Ho, Anthony D.
Tanaka, Motomu
description Supramolecular Hydrogels In article 2302607, Motomu Tanaka and co‐workers show that reversible host‐guest crosslinks in supramolecular hydrogels enable on‐demand mechanical stimulation of human mesenchymal stem cells. A subtle change in substrate stiffness across the critical threshold turns on and off cell traction force and YAP/TAZ signaling, followed by shape adaptation. A frequent mechanical stress beyond the critical frequency suppresses the stem cell proliferation with no loss of multipotency.
doi_str_mv 10.1002/adhm.202470071
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title Reversible Host–Guest Crosslinks in Supramolecular Hydrogels for On‐Demand Mechanical Stimulation of Human Mesenchymal Stem Cells (Adv. Healthcare Mater. 10/2024)
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