Electrical Detection of Femtomolar DNA via Gold-Nanoparticle Enhancement in Carbon-Nanotube-Network Field-Effect Transistors

A dramatic sensitivity enhancement in electrical detection of DNA hybridization using single‐walled carbon nanotube networked field effect transistors (SNFETs) via introducing reporter DNA‐Au nanoparticle (AuNP) conjugates in the hybridization step is reported. The amplified change in drain current...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2008-06, Vol.20 (12), p.2389-2393
Main Authors: Dong, Xiaochen, Lau, Ching Man, Lohani, Anup, Mhaisalkar, Subodh G., Kasim, Johnson, Shen, Zexiang, Ho, Xinning, Rogers, John A., Li, Lain-Jong
Format: Article
Language:English
Subjects:
conjugation
field-effect transistors
gold nanoparticles
hybrid materials
single-walled carbon nanotubes
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Summary:A dramatic sensitivity enhancement in electrical detection of DNA hybridization using single‐walled carbon nanotube networked field effect transistors (SNFETs) via introducing reporter DNA‐Au nanoparticle (AuNP) conjugates in the hybridization step is reported. The amplified change in drain current allows to reliably determine the DNA concentration down to ∼100 fM.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200702798