Enantioselective Hydrogenation of Imines Using a Diverse Library of Ruthenium Dichloride(diphosphine)(diamine) Precatalysts

A range of aromatic and cyclic imines were subjected to asymmetric hydrogenation with catalysts derived from complexes of the type RuCl2(diphosphine)(diamine). Good to high enantioselectivities were observed. For each imine, a library of chiral complexes based on different diphosphine and diamine co...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2003-01, Vol.345 (1-2), p.195-201
Main Authors: Cobley, Christopher J., Henschke, Julian P.
Format: Article
Language:English
Subjects:
Asymmetric hydrogenation
DuPHOS
imine hydrogenation
ruthenium
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Summary:A range of aromatic and cyclic imines were subjected to asymmetric hydrogenation with catalysts derived from complexes of the type RuCl2(diphosphine)(diamine). Good to high enantioselectivities were observed. For each imine, a library of chiral complexes based on different diphosphine and diamine combinations was screened. A different combination of diphosphine and diamine was required each time to obtain the optimum enantioselectivity.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200390011