An Efficient Approach to Chiral Ferrocene-Based Secondary Alcohols via Asymmetric Hydrogenation of Ferrocenyl Ketones

P‐Phos‐ruthenium‐DPEN precatalysts have been found to be efficient for the asymmetric hydrogenation of various ferrocenyl ketones. The use of (R)‐xylyl‐P‐PhosRuCl2(R,R)‐DPEN generated chiral ferrocenylethanol in 99.3% e.e. with >99% conversion in a 150‐g scale.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2006-02, Vol.348 (3), p.370-374
Main Authors: Lam, Wing-Sze, Kok, Stanton H. L., Au-Yeung, Terry T.-L., Wu, Jing, Cheung, Hong-Yee, Lam, Fuk-Loi, Yeung, Chi-Hung, Chan, Albert S. C.
Format: Article
Language:English
Subjects:
asymmetric catalysis
ferrocenyl ketone
homogeneous catalysis
hydrogenation
P-Phos
ruthenium
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Description
Summary:P‐Phos‐ruthenium‐DPEN precatalysts have been found to be efficient for the asymmetric hydrogenation of various ferrocenyl ketones. The use of (R)‐xylyl‐P‐PhosRuCl2(R,R)‐DPEN generated chiral ferrocenylethanol in 99.3% e.e. with >99% conversion in a 150‐g scale.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200505321