Convenient Preparation of Chiral α,β-Epoxy Ketones via Claisen-Schmidt Condensation-Epoxidation Sequence

A novel Clasisen–Schmidt condensation‐epoxidation sequence of aldehydes and ketones was developed to produce a series of chiral α,β‐epoxy ketones under asymmetric phase‐transfer catalytic conditions. The organocatalytic method reported here can afford chiral α,β‐epoxy ketones under mild conditions w...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2007-05, Vol.349 (7), p.1033-1036
Main Authors: Wang, Yongcan, Ye, Jinxing, Liang, Xinmiao
Format: Article
Language:English
Subjects:
aldehydes
asymmetric catalysis
condensation
epoxidation
ketones
one-pot
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel Clasisen–Schmidt condensation‐epoxidation sequence of aldehydes and ketones was developed to produce a series of chiral α,β‐epoxy ketones under asymmetric phase‐transfer catalytic conditions. The organocatalytic method reported here can afford chiral α,β‐epoxy ketones under mild conditions with moderate to good yields and up to 96 % ee.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200600592