Organocatalytic Enantioselective Synthesis of Pyrazolidines, Pyrazolines and Pyrazolidinones

Enantiopure pyrazolidines, pyrazolines and pyrazolidinones have been accessed in a direct and efficient manner through an organocatalytic, enantioselective aza‐Michael/hemiaminal formation cascade process from enals and N,N′‐disubstituted hydrazides. The process takes place with high regio‐ and ster...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2012-02, Vol.354 (2-3), p.371-376
Main Authors: Fernández, Maitane, Reyes, Efraím, Vicario, Jose L., Badía, Dolores, Carrillo, Luisa
Format: Article
Language:English
Subjects:
asymmetric catalysis
Catalysis
Catalysts: preparations and properties
Chemistry
domino reaction
Exact sciences and technology
General and physical chemistry
heterocycles
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
hydrazines
Organic chemistry
organocatalysis
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Summary:Enantiopure pyrazolidines, pyrazolines and pyrazolidinones have been accessed in a direct and efficient manner through an organocatalytic, enantioselective aza‐Michael/hemiaminal formation cascade process from enals and N,N′‐disubstituted hydrazides. The process takes place with high regio‐ and stereoselectivities and furnishes the target compounds in high overall yields by means of an operationally very simple methodology.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201100722