Front Cover Picture: Asymmetric Synthesis of Trisubstituted Piperidines via Biocatalytic Transamination and Diastereoselective Enamine or Imine Reduction (Adv. Synth. Catal. 13/2023)

The front cover picture shows the assembly of a trisubstituted piperidine derivative through the controlled formation of C−N and C−H bonds. Different stereoselective synthetic tools – namely transaminase and IRED enzymes, and platinum(0)‐catalysed flow hydrogenation – are combined to obtain the targ...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2023-07, Vol.365 (13), p.2057-2057
Main Authors: Petermeier, Philipp, Kohlfuerst, Christoph, Torvisco, Ana, Fischer, Roland C., Mata, Alejandro, Dallinger, Doris, Kappe, C. Oliver, Schrittwieser, Joerg H., Kroutil, Wolfgang
Format: Article
Language:English
Subjects:
Asymmetric Synthesis
Flow Hydrogenation
Imine Reductase
Piperidine
Transaminase
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The front cover picture shows the assembly of a trisubstituted piperidine derivative through the controlled formation of C−N and C−H bonds. Different stereoselective synthetic tools – namely transaminase and IRED enzymes, and platinum(0)‐catalysed flow hydrogenation – are combined to obtain the target N‐heterocycles from achiral, open‐chain precursors with excellent enantio‐ and diastereocontrol. The cover design is by Verena Resch and used with her permission. Details can be found in the Research Article by Joerg Schrittwieser and co‐workers (P. Petermeier, C. Kohlfuerst, A. Torvisco, R. C. Fischer, A. Mata, D. Dallinger, C. O. Kappe, J. H. Schrittwieser, W. Kroutil, Adv. Synth. Catal. 2023, 365, 2188–2202; DOI: 10.1002/adsc.202300050).
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300365